ELASTASE ACTIVITY OF THE ORAL FLUID OF PATIENTS WITH PYOINFLAMMATORY PROCESSES
IN MAXILLOFACIAL AREA 

Kabanova Arina Aleksandrovna, Candidate of medical science, associate professor, sub-department of children dentistry and maxillofacilal surgery, Vitebsk State Medical University
(27 Frunze avenue, Vitebsk, Belarus), arinakabanova@mail.ru
Okulich Vitaliy Konstantinovich, Candidate of medical sciences, associate professor, sub-department of clinical microbiology, Vitebsk State Medical University (27 Frunze avenue, Vitebsk, Belarus), vokul@mail.ru
Goncharova Anna Igorevna, Postgraduate student, Vitebsk State Medical University (27 Frunze avenue, Vitebsk, Belarus), anna2569@yandex.by
Usovich Aleksandr Konstantinovich, Doctor of medical sciences, professor, head of sub-department of human anatomy, Vitebsk State Medical University (27 Frunze avenue, Vitebsk, Belarus), usovicha@mail.ru
Denisenko Aleksandr Grigor'evich, Candidate of medical sciences, assistant, sub-department of forensic medicine, Vitebsk State Medical University (27 Frunze avenue, Vitebsk, Belarus), denisenko_1976@mail.ru

616.716.8 – 002.36:575.15

Background. The article aims at studying elastase activity of the oral fluid of patients with pyoinflammatory diseases of maxillofacial area. Materials and methods. Complex examination of 45 patients with pyoinflammatory processes of the maxillo-facial area and 22 healthy people was carried out. Using the modified method of Kyung-Hwan and Kim Hyong the activity of the enzyme elastase of oral fluid was studied.
Results. The authors determined that the activity of the oral fluid elastase increases with development of odontogenic and nonodontogenic inflammatory diseases of maxillofacial area, and the relief of the acute inflammatory processes causes nor-malization of enzyme activity. Patients with extensive inflammatory processes have a higher elastase activity than patients with local processes.
Summary. Further study of the oral fluid elastase activity of the patients with inflammatory processes of the maxillofacial area will lead to development of noninvasive diagnostic tests.

elastase, oral fluid, pyoinflammatory processes, maxillofacial area

1. Agapov V. S., Artyunov S. D., Shulakov V. V. Infektsionnye vospalitel'nye zabolevaniya chelyustno-litsevoy oblasti [Infectious inflammatory diseases of maxillofacilal area]. Moscow: MIA, 2004, 184 p.
2. Heymans O. et al. Rev. Med. Liege. 2002, vol. 57, no. 9, pp. 587–590.
3. Kabanova S. A. et al. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta [Bulletin of Vitebsk State Medical University]. 2003, vol. 2, no. 1, pp. 35–40.
4. Giamarellou H., Antoniadou A. Infect. Control Hosp. Epidemiol. 1996, vol. 17, no. 8, pp. 558–564.
5. Aver'yanov A. V. Tsitokiny i vospalenie [Cytokine and inflammation]. 2007, vol. 6, no. 4, pp. 3–8.
6. Kosinets A. N., Struchkov Yu. V. Infektsiya v khirurgii: Rukovodstvo [Infection in surgery: guide]. Vitebsk: Izd-vo VGMU, 2004, 510 p.
7. Supotnitskiy M. Mikroorganizmy, toksiny i epidemii [Microorganisms, toxins and epidemics]. Moscow: Vuzovskaya kniga, 2000, 376 p.
8. Klimenkova Yu. G. et al. Studencheskaya meditsinskaya nauka XXI veka: materialy KhIII Mezhdunar. nauch.-prakt. konf. [Student medical science of XXI century: proceedings of XIII International scientific and practical conference]. Vitebsk. gos. med. un-t., 2013, pp. 267–268.
9. Ohman D. E., Cryz S. J., Iglewski B. H. J. Bacteriol. 1980, no. 142, pp. 836–842.